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第七届类肉瘤病及其他肉芽肿性疾患国际会议,把全身性类肉瘤病描写为不知病原体和发病原因的多系统肉芽肿病症。最常见的累及部位是纵膈及外周的淋巴结、肺、肝、脾、皮肤、眼睛、指骨和腮腺。临床上类肉瘤病的症状是一般性的,双侧肺门和颈部淋巴结肿大,可出现疲劳,呼吸困难和体重下降。血浆球蛋白增高和高钙尿症。 类肉瘤病的组织学表现为非干酪样变。上皮样小结无周围淋巴细胞浸润,也有多核巨细胞。对类肉瘤病的主要鉴别有结核、胶原病,例如,类风湿性关节炎、霉菌感染、麻疯、梅毒、异物反应和赘瘤,何杰金氏病的肉芽肿期。
The Seventh International Symposium on Sarcoidosis and Other Granulomatous Disorders, describes systemic sarcoidosis as a multi-system granulomatous disease of unknown origin and causative agent. The most common sites of involvement are mediastinal and peripheral lymph nodes, lungs, liver, spleen, skin, eyes, phalanges and parotid glands. The clinical symptoms of sarcoidosis are general, bilateral hilar and neck lymph nodes, fatigue, dyspnea and weight loss may occur. Increased plasma globulin and hypercalciuria. The histological appearance of sarcoidosis is not caseous. Epithelial nodules without peripheral lymphocyte infiltration, but also multinucleated giant cells. The main identifications for sarcoidosis are tuberculosis, collagen diseases such as rheumatoid arthritis, mold infections, leprosy, syphilis, foreign body reactions and neoplasms, and granuloma of Hodgkin’s disease.