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目的：对粘痰溶解剂氨溴索（Ａｍｂ）与第三代口服头孢菌素头孢克肟（Ｃｅｆ）合用后Ｃｅｆ肺渗透性进行研究，为临床二者合用提供理论依据。方法：１６例呼吸系患者随机分为两组；Ｃｅｆ组给予Ｃｅｆ０．１ｇ，Ｂｉｄ，连服３ｄ；Ｃｅｆ＋Ａｍｂ组除同Ｃｅｆ组给予Ｃｅｆ外，加服Ａｍｂ６０ｍｇ，Ｔｉｄ，连服３ｄ。于最后一次服药后３ｈ行支气管肺泡灌洗术，收集支气管肺泡灌流液（ＢＡＬ），同时收集病人血浆。用固相萃取技术富集、纯化血浆及ＢＡＬ中Ｃｅｆ之后，采用ＨＰＬＣ测定Ｃｅｆ浓度。结果：Ｃｅｆ组和Ｃｅｆ＋Ａｍｂ组血浆浓度分别为０．９±０．７，０．９±０．４ｍｇ·Ｌ－１，ＢＡＬ中Ｃｅｆ浓度分别为０．０２２±０．０１１，０．０３７±０．０１４ｍｇ·Ｌ－１。结论：Ａｍｂ与Ｃｅｆ同服可增加肺部Ｃｅｆ浓度
OBJECTIVE: To study the permeability of Cef lungs after combination of ambroxol (Amb) and cefotaxime (Cef), which is the third-generation oral cephalosporin, and provide a theoretical basis for their combination. Methods: Sixteen patients with respiratory system were randomly divided into two groups: Cef 0.1g, Bid, and even served 3d; Cef + Amb plus Cef plus Ce 60mg, Tid plus even served 3d. Bronchial alveolar lavage was performed 3h after the last dose, bronchoalveolar lavage fluid (BAL) was collected, and the patient’s plasma was collected. After enrichment with solid-phase extraction and purification of Cef in plasma and BAL, the Cef concentration was determined by HPLC. RESULTS: The plasma concentrations of Cef and Cef + Amb were 0.9 ± 0.7 and 0.9 ± 0.4 mg · L -1, respectively. The Cef concentrations in BAL were 0.022 ± 0.011 and 0.037 ± 0 .014 mg · L-1. Conclusion: Amb and Cef can increase the lung Cef concentration