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【目的】探讨纹状体源性神经营养因子 (SDNF)在帕金森病 (PD)治疗方面的应用前景。【方法】建立 6 羟基多巴胺 (6 OHDA)诱导的大鼠“半”PD模型 ,进行早期一次性注射SDNF ,以及损伤两周后重复注射SDNF ,以观察SDNF对模型鼠的治疗作用。【结果】早期一次性注射SDNF能明显阻止中脑黑质多巴胺 (DA)神经元数量的减少。而损伤两周后重复注射SDNF ,虽不再能改变DA神经元的数量 ,但能降低模型鼠由阿朴吗啡 (APO)诱导的旋转 ,以及增加损伤侧纹状体内DA含量和降低HVA(高香草酸 ) /DA值。【结论】SDNF对 6 OHDA诱导的中脑DA神经元的变性有阻止作用 ,同时对残留DA神经元的功能有增强作用。
【Objective】 To investigate the application of striatal-derived neurotrophic factor (SDNF) in the treatment of Parkinson’s disease (PD). 【Methods】 A rat model of “half” PD induced by 6-hydroxydopamine (6 OHDA) was established. SDNF was injected in the early stage and repeated injections of SDNF two weeks after the injury to observe the therapeutic effect of SDNF on the model mice. 【Results】 The early one-time injection of SDNF could obviously prevent the decrease of dopamine (DA) neurons in midbrain substantia nigra. Repeated injection of SDNF two weeks after injury, although no longer able to change the number of DA neurons, but can reduce apomorphine (APO) -induced rotation of the model mice, as well as increase the damaging striatum DA content and reduce HVA (high Vanillic acid) / DA value. 【Conclusion】 SDNF can inhibit the degeneration of DA neurons induced by 6 OHDA in midbrain and enhance the function of residual DA neurons.