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目的:探讨分析不同三联疗法治疗慢性萎缩性胃炎的临床疗效。方法:选择2012年4月至2014年4月期间至我科就诊的明确诊断为慢性萎缩性胃炎的患者80例,随机分为两组,治疗组采用埃索美拉唑+丽珠得乐+克拉霉素的新三联疗法治疗,对照组采用奥美拉唑+果胶铋+阿司匹林的旧三联疗法治疗,通过观察治疗前后两组胃镜检查胃黏膜萎缩的改善情况来对比分析治疗组和对照组不同治疗方法的疗效。结果:胃黏膜腺体无萎缩和轻、中、重度萎缩的例数和所占比率,治疗组治疗前分别为2(5%)、16(40%)、14(35%)、8(20%),治疗后分别为19(47.5%)、8(20%)、7(17.5%)、6(15%);对照组治疗前分别为3(7.5%)、12(30%)、18(45%)、7(17.5%),治疗后分别为18(45%)、10(25%)、8(20%)、4(10%)。结论:说明治疗组的埃索美拉唑+丽珠得乐+克拉霉素的新三联疗法能更好改善慢性萎缩性胃炎患者的胃黏膜腺体萎缩情况,从而可以改善患者临床症状,提高临床疗效,改善患者生活质量。药物的研究对于慢性胃炎的治疗有着重要的临床意义和广阔的前景,值得进一步研究和临床应用。
Objective: To investigate the clinical efficacy of different triple therapy in the treatment of chronic atrophic gastritis. Methods: Eighty patients with definite diagnosis of chronic atrophic gastritis who were admitted to our department from April 2012 to April 2014 were randomly divided into two groups. The patients in the treatment group were treated with esomeprazole + The new triple therapy of clarithromycin, the control group with omeprazole + pectin bismuth + aspirin old triple therapy, by observing the two groups before and after gastroscopy gastric mucosal atrophy improved to compare the treatment group and the control group Therapeutic efficacy of different treatments. Results: There was no atrophy and the number of mild, moderate and severe atrophy cases in the gastric mucosal gland and the proportion of the patients were 2 (5%), 16 (40%), 14 (35%), 8 (7.5%), 12 (30%) and 18 (18%) before treatment in the control group, respectively. After treatment, they were 19 (47.5%), 8 (45%), 7 (17.5%) and 18 (45%), 10 (25%), 8 (20%) and 4 (10%) after treatment, respectively. Conclusions: The new triple therapy of esomeprazole + levocephalex + clarithromycin in the treatment group can better ameliorate gastric mucosal glandular atrophy in patients with chronic atrophic gastritis, which can improve the clinical symptoms and improve clinical Efficacy, improve patient quality of life. Drug research for the treatment of chronic gastritis has important clinical significance and broad prospects, it is worth further study and clinical application.