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目的测定肝硬化患者血清脂联素与瘦素的水平并探讨二者的相关性。方法测定73例肝硬化患者和30例健康对照的血清脂联素和瘦素及相关的临床生化参数,计算血清脂联素/瘦素比值。结果肝硬化患者血清脂联素、瘦素水平明显高于正常对照组(P<0.05);脂联素/瘦素比值>1;血清脂联素与瘦素水平呈正相关。血清脂联系、瘦素水平与胰岛素、胰岛素抵抗指数呈正相关,与胰岛素敏感指数呈负相关。结论肝硬化患者血清脂联素、瘦素水平和脂联素/瘦素比值明显升高,可能与肝硬化患者胰岛素抵抗有关。
Objective To determine the serum levels of adiponectin and leptin in patients with cirrhosis and to explore their correlation. Methods Serum adiponectin, leptin and related clinical biochemical parameters were measured in 73 patients with cirrhosis and 30 healthy controls, and the serum adiponectin / leptin ratio was calculated. Results Serum levels of adiponectin and leptin in patients with cirrhosis were significantly higher than those in the normal control group (P <0.05). The adiponectin / leptin ratio was higher than 1; serum adiponectin and leptin levels were positively correlated. Serum lipid, leptin levels and insulin, insulin resistance index was positively correlated, and insulin sensitivity index was negatively correlated. Conclusions Serum levels of adiponectin, leptin and adiponectin / leptin were significantly increased in patients with cirrhosis, which may be related to insulin resistance in cirrhotic patients.