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目的 探讨p16蛋白、nm2 3蛋白及c erbB 2蛋白在脑胶质瘤发生、发展中的作用。方法 应用免疫组织化学技术检测 60例脑胶质瘤中 p16蛋白、nm2 3蛋白及c erbB 2蛋白的表达。结果 p16蛋白、nm2 3蛋白及c erbB 2蛋白在脑胶质瘤和正常脑组织中的阳性表达率分别为43 .3 %和 90 % (P <0 .0 5 ) ;3 6.7%和 80 % (P <0 .0 5 ) ;41.7%和 0 (P <0 .0 5 )。脑胶质瘤中 p16蛋白及nm2 3蛋白缺失率在死亡组和生存组分别为 73 .7%和 3 1.8% (P <0 .0 5 ) ;84.2 %和 3 6.3 %(P <0 .0 5 ) ;c erbB 2蛋白过度表达率在死亡组和生存组为 68.4%和 2 7.2 % (P <0 .0 5 )。结论 p16蛋白、nm2 3蛋白缺失和c erbB 2蛋白过度表达与脑胶质瘤发生、发展密切相关。
Objective To investigate the role of p16 protein, nm23 protein and c erbB 2 protein in the pathogenesis of glioma. Methods Immunohistochemistry was used to detect the expression of p16, nm23 and c-erbB-2 in 60 gliomas. Results The positive rates of p16, nm23 and c-erbB-2 in gliomas and normal brain tissues were 43.3% and 90%, respectively (P <0.05) (P <0.05); 41.7% and 0 (P <0.05). The loss rates of p16 protein and nm23 protein in gliomas were 73.7% and 38.1% (P <0.05), 84.2% and 6.3% (P <0. 0) in the death group and the survival group 5). The overexpression rate of c erbB 2 was 68.4% and 7.2% in the death group and the survival group (P <0.05). Conclusion The loss of p16 protein, nm23 protein and overexpression of c erbB 2 are closely related to the occurrence and development of glioma.