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目的:通过对血清相关指标的分析,研究东莨菪碱对重型颅脑损伤的保护作用,同时观察东莨菪碱对重型颅脑损伤的预后影响。方法:选择确诊为重型创伤性脑损伤患者87例,随机分为对照组与观察组,对照组42例采用常规外科治疗,观察组45例在常规外科治疗的基础上加用东莨菪碱治疗,比较两组患者治疗后12h、24h、48h、72h血清SOD、GPx和MDA水平,并根据GOS标准,比较两组患者治疗6个月后的临床疗效。结果:治疗72h后,两组患者血清SOD、GPx和MDA水平比较具有统计学意义(P<0.05);术后6个月,两组患者优良率和死亡率比较具有统计学意义(P<0.05)。结论:术后使用东莨菪碱静脉推注治疗,可减轻脑组织损伤,促进脑组织的恢复,提高临床治疗效果,此方法安全有效,值得临床广泛推广。
OBJECTIVE: To study the protective effect of scopolamine on severe craniocerebral injury by analyzing the serum related indicators, and to observe the effect of scopolamine on the prognosis of severe craniocerebral injury. Methods: A total of 87 patients with severe traumatic brain injury were selected and randomly divided into control group and observation group. In the control group, 42 cases were treated by conventional surgery. In the observation group, 45 cases were treated with scopolamine on the basis of conventional surgical treatment. The levels of serum SOD, GPx and MDA were measured at 12h, 24h, 48h, 72h after treatment in the two groups. According to GOS criteria, the clinical efficacy of the two groups was compared after 6 months of treatment. Results: The serum SOD, GPx and MDA levels of the two groups were statistically significant after 72 hours of treatment (P <0.05). At 6 months after operation, the excellent and good rates of mortality and mortality of the two groups were statistically significant (P <0.05 ). Conclusion: The intravenous injection of scopolamine after operation can reduce the damage of brain tissue, promote the recovery of brain tissue and improve the effect of clinical treatment. This method is safe and effective and should be widely popularized in clinic.