论文部分内容阅读
目的为筛选与糖尿病肾病（ＤＮ）有关的危险因素，并了解各因素在ＤＮ发病中各自独立的作用及相对影响大小。方法采用多元逐步回归的统计方法对１０６例Ⅱ型糖尿病（ＤＭ）患者的临床及生化指标进行分析。结果①存在微量白蛋白尿的患者占总病例数的３０．１％；②Ⅱ型ＤＭ合并异常白蛋白尿组和正常白蛋白尿组相比，前组年龄、病程、体重指数、空腹Ｃ－肽、ａｐｏＢ１００和Ｌｐ（ａ）均高于后组；③与ＤＮ相关的危险因素依次为ａｐｏＢ１００、舒张压、空腹血糖、餐后２ｈＣ－肽、病程、年龄、Ｌｐ（ａ）和餐后２ｈ胰岛素。结论血脂异常、高血压、高血糖及高胰岛素血症是ＤＮ发病的主要危险因素。积极纠正血脂异常，控制血压、血糖以及改善胰岛素抵抗状态是预防和延缓ＤＮ发生发展的有效手段。
Objective To screen for the risk factors associated with diabetic nephropathy (DN) and to understand the independent role of each factor in the pathogenesis of DN and the relative impact size. Methods The clinical and biochemical indexes of 106 type Ⅱ diabetic patients were analyzed by multivariate stepwise regression. Results ① The patients with microalbuminuria accounted for 30.1% of the total number of cases. ②Compared with normal albuminuria group, the age, course of disease, body mass index, fasting C-peptide , ApoB100 and Lp (a) were higher than the latter group. ③The risk factors associated with DN were apoB100, diastolic blood pressure, fasting blood glucose, postprandial 2h C-peptide, duration of disease, age, Lp (a) and 2h postprandial insulin. Conclusion Dyslipidemia, hypertension, hyperglycemia and hyperinsulinemia are the main risk factors of DN. Active correction of dyslipidemia, blood pressure control, blood glucose and improve insulin resistance status is to prevent and delay the occurrence and development of DN an effective means.