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目的:观察口服丁基苯酞(NBP)对小鼠的抗疲劳和抗缺氧作用,探讨其可能的作用机理。方法:①抓环试验:观察口服NBP对小鼠悬挂时间、血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响;②力竭游泳试验:观察口服NBP对小鼠游泳力竭时间,及血清乳酸脱氢酶(LDH)活性、乳酸(LA)含量、SOD活性和MDA含量的影响;③常压缺氧试验:观察口服NBP对小鼠缺氧时的存活时间、脑组织中SOD活性和MDA含量的影响。结果:NBP延长小鼠的抓握时间、力竭游泳时间和常压缺氧耐受时间,提高缺氧小鼠脑组织SOD和LDH活性。结论:NBP具有抗疲劳和抗缺氧作用,抗缺氧的机理可能与其抗氧化作用和改善能量代谢作用有关。
OBJECTIVE: To observe the anti-fatigue and anti-hypoxic effects of oral butylphthalide (NBP) on mice and to explore its possible mechanism. Methods: (1) Catheterization test: The effects of oral NBP on the suspension time, the activity of serum superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in mice were observed. Exhausted swimming test: Exhaustion time, serum lactate dehydrogenase (LDH) activity, lactate (LA) content, SOD activity and MDA content; ③ Hypobaric hypoxia test: Observe the survival time, Effect of SOD activity and MDA content in tissues. Results: NBP prolonged the holding time, exhausted swimming time and hypoxia tolerance time in mice, and increased the activities of SOD and LDH in the brain of hypoxic mice. Conclusion: NBP has anti-fatigue and anti-hypoxic effects. The mechanism of anti-hypoxia may be related to its anti-oxidation and energy metabolism.