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目的:探讨紫癜性肾炎(APN)、过敏性紫癜(AP)和正常对照组血中血管细胞粘附分子-1(VCAM-1)、血管内皮生长因子(VEGF)和β2-微球蛋白(β2-MG)的含量变化,以及AP中VCAM-1、VEGF和β2-MG之间的相关性,以证实VCAM-1和VEGF参与了AP的部分发病机制。方法:采用ELISA法,检测APN组22例,AP组28例及健康儿童30名为正常对照组的血浆中VCAM-1和VEGF的含量。生化分析仪检测三组儿童的血β2-MG。比较APN组、AP组和正常对照组之间VCAM-1、VEGF和β2-MG的差异,及三者间的相关性分析。结果:血浆VCAM-1含量、VEGF含量和血中β2-MG含量均APN组>AP组>正常对照组,差异均有统计学意义(P<0.01);在APN和AP组中,血浆VCAM-1、VEGF和血β2-MG散点图呈线性趋势,均呈正相关。三者间相关性分析均r>0(P<0.01)。结论:儿童AP血浆VCAM-1、VEGF和血β2-MG含量升高,APN均比AP更高,且三者间均呈正相关。示三者均参与了AP的部分发病机制。
OBJECTIVE: To investigate the expression of vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor (VEGF) and β2-microglobulin (β2) in purpura nephritis (APN), allergic purpura (AP) and normal control -MG), and the correlation between VCAM-1, VEGF and β2-MG in AP to confirm the involvement of VCAM-1 and VEGF in the pathogenesis of AP. Methods: The plasma concentrations of VCAM-1 and VEGF in 22 APN patients, 28 AP patients and 30 normal children were detected by ELISA. Biochemical analyzer test three groups of children’s blood β2-MG. The differences of VCAM-1, VEGF and β2-MG between the APN group, the AP group and the normal control group were compared and their correlations were analyzed. Results: The levels of VCAM-1, VEGF and β2-MG in plasma were significantly higher in APN group than AP group and normal control group (P <0.01). In APN and AP group, plasma VCAM- 1, VEGF and blood β2-MG scatter plot showed a linear trend, were positively correlated. The correlation between the three were r> 0 (P <0.01). CONCLUSION: The content of plasma VCAM-1, VEGF and blood β2-MG in children with AP are higher than those in AP, and all have a positive correlation. Show all three are involved in part of the pathogenesis of AP.