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目的探讨脂多糖结合蛋白(LBP)、血清淀粉样蛋白A(SAA)和降钙素原(PCT)在自发性腹膜炎(SBP)患者中的表达水平及其应用价值。方法选取2012年1月-2014年6月肝硬化腹水患者125例,分为SBP组64例,非SBP组61例。采用酶联免疫吸附法(ELISA)检测LBP,采用免疫比浊法检测SAA,采用免疫化学发光法(ILMA)测定PCT。结果 LBP、SAA和PCT在SBP组表达水平显著高于非SBP组和对照组,差异有统计学意义(P<0.05);治疗有效患者治疗前的LBP、SAA和PCT表达水平显著高于治疗后恢复期,差异有统计学意义(P<0.05);LBP、SAA和PCT在死亡组表达水平显著高于存活组,差异有统计学意义(P<0.05)。结论 SBP患者血清LBP、SAA和PCT均有较高的表达,并与疾病严重程度及预后密切相关。
Objective To investigate the expression of lipopolysaccharide binding protein (LBP), serum amyloid A (SAA) and procalcitonin (PCT) in patients with spontaneous peritonitis (SBP) and its clinical value. Methods From January 2012 to June 2014, 125 patients with cirrhosis and ascites were divided into 64 cases in SBP group and 61 cases in non-SBP group. LBP was detected by enzyme-linked immunosorbent assay (ELISA), SAA by immunoturbidimetric assay, and PCT assay by immunochemiluminescence (ILMA). Results The expression levels of LBP, SAA and PCT in SBP group were significantly higher than those in non-SBP group and control group (P <0.05). The levels of LBP, SAA and PCT before treatment were significantly higher in treatment-effective patients than those in treatment group (P <0.05). The expression levels of LBP, SAA and PCT in the death group were significantly higher than those in the survival group, the difference was statistically significant (P <0.05). Conclusions Serum levels of LBP, SAA and PCT in SBP patients are higher than those in other groups, and are closely related to the severity and prognosis of SBP.