Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice

• 作 者: Huiling Cao Qinnan Yan Dong Wa
• 机 构: GuangdongProvincialKeyLaboratoryofCellMicroenvironmentandDiseaseResearch,KeyLaboratoryofNeuroregener
• 出 处: 骨研究:英文版
• 发表日期: 2020年1期
• 关键词: HOMEOSTASIS Kindlin cytes
• 基金项目: the National Natural Science Foundation of China Grants(81991513,81630066 and 81870532),by a Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018),by Shenzhen Municipal

Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts b