论文部分内容阅读
合成具有高效抗病毒，抗癌，抗－ＨＩＶ活性的拟核苷类药物和探索这类化合物的化学结构与生物活性作用的关系已成为有机合成的一个很热门研究课题。在化学合成方面主要着重于核糖结构或碱基结构的优化处理以便提高这类物质的生物活性。概述了目前该领域从天然核苷的结构优化到人工合成拟核苷类药物研究过程的一系列新进展。针对以异恶唑烷（恶唑啉）杂环取代核苷中的核糖结构为代表的拟核苷类化合物的最新研究思路及合成方法作了详细归纳。并简单介绍该领域内较适用的符号表示系统的应用。
The synthesis of nucleoside drugs with high antiviral, anti-cancer and anti-HIV activity and the exploration of the relationship between the chemical structure and bioactivity of these compounds have become a hot research topic in organic synthesis. In chemical synthesis, the emphasis is on the optimization of ribose structure or base structure in order to increase the biological activity of such substances. The current progress in the field of structural optimization of natural nucleosides to the synthesis of synthetic nucleosides has been summarized. The recent research ideas and synthetic methods of the nucleosides represented by ribose structures substituted with isoxazolidine (oxazoline) heterocyclic nucleosides are summarized in detail. And briefly introduces the application of the more applicable symbolic representation system in this field.