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【目的】评价早期干预对早产儿早期神经心理和视觉系统发育的影响,为开展系统的早产儿早期干预提供临床依据。【方法】对干预组早产儿进行定期随访并实施早期干预;于矫正6月龄时对随访≥3次的干预组早产儿、常规随访的未干预组早产儿进行贝莉婴儿发育量表-II(BSID-II)和闪光视觉诱发电位(flash visual evoked potentials,FVEP)测试。【结果】两组早产儿BSID-II测试结果显示,干预组的MDI值、PDI值比未干预组早产儿分别高出9.12分和6.35分,差异有显著的统计学意义;两组早产儿FVEP测试显示:干预组FVEP的P1波潜伏期较未干预组早产儿缩短,差异有统计学意义(P<0.05),N1波、N2波潜伏期和N1P1振幅两组间差异无统计学意义。【结论】有效的早期干预可以促进早产儿早期认知功能和视觉系统的发育;将BSID-II和FVEP相结合的评价,能从认知行为表达和脑电生理两方面更客观而全面地评价早产儿的发育状态;有待于进一步探索早期干预实施对儿童认知发展的远期影响。
【Objective】 To evaluate the effect of early intervention on early neuropsychological and visual system development in preterm infants and provide a clinical basis for the early intervention of systemic premature infants. 【Methods】 Regular follow-up and early intervention were carried out in preterm infants of intervention group. Preterm infants of preterm infants of follow-up ≥3 times were enrolled in the correction of 6-month-old infants, (BSID-II) and flash visual evoked potentials (FVEP) tests. 【Results】 The results of BSID-II in preterm infants in both groups showed that the MDI and PDI in intervention group were 9.12 and 6.35 points higher than those in non-intervention group, respectively, with significant difference between the two groups The results showed that the latency of P1 wave in FVEP group was shorter than that in non-intervention group, the difference was statistically significant (P <0.05). There was no significant difference between N1 wave amplitude and N1 wave amplitude in intervention group. 【Conclusion】 Effective early intervention can promote the early cognitive function and visual system development in premature infants. The combination of BSID-II and FVEP can evaluate more objectively and comprehensively both in cognitive behavioral and brain electrophysiology The developmental status of premature babies needs further exploration of the long-term effects of early intervention on children’s cognitive development.