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目的探讨1H磁共振波谱(1HMRS)对脑胶质瘤放疗后疗效监测和预后评估的应用价值。方法10例经手术病理或临床证实的脑胶质瘤患者,接受40～50Gy的脑部放射治疗,随访进行1HMRS检查和磁共振检查。结果放疗后3～6个月治疗有效3例,1HMRS表现为Cho下降或明显下降,Cho/Cr明显升高;放疗后1年以上肿瘤放射坏死6例中,NAA、Cr、Cho明显降低或消失;1例2年后肿瘤复发出现明显升高的Cho峰。结论1HMRS可以作为临床监测放疗疗效和评估预后的一种手段。
Objective To investigate the value of 1H magnetic resonance spectroscopy (1HMRS) in the monitoring and prognosis evaluation of glioma after radiotherapy. Methods Ten patients with pathologically confirmed or clinically proven gliomas underwent brain irradiation of 40-50 Gy and were followed up for 1H MRS and MR examinations. Results 3 to 6 months after radiotherapy, 3 cases were treated effectively, and 1HMRS showed a decrease or a significant decrease of Cho and a significant increase of Cho / Cr. NAA, Cr and Cho significantly decreased or disappeared in 6 cases of radiotherapy and necrosis ; 1 case 2 years after tumor recurrence significantly increased Cho peak. Conclusion 1HMRS can be used as a means of clinical monitoring of radiotherapy efficacy and prognosis.