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目的 观察BVMAP方案治疗难治性非霍奇金淋巴瘤的疗效。方法 采用博莱霉素 10mg/m2 肌肉注射 ,第 1、3、5天 ;长春地辛 3mg/m2 ,静脉滴注 ,第 1、8天 ;氨甲喋呤 12 0mg/m2 ,静脉滴注 ,第 1、8天 ;阿糖胞苷 6 0mg/m2 ,静脉滴注 ,第 1～ 5天 ;强的松 (PDN ) 30mg/m2 ,口服 ,第 1～ 14天。 2 8天为 1个周期 ,连续用药 2个周期以上评价疗效。结果 全组 2 0例 ,CR 5例 ,PR 7例 ,NC 6例 ,PD 2例 ,有效率为 6 0 %。不良反应主要是白细胞和血小板下降 ,发生率分别为 90 %和 5 0 %。结论 BVMAP方案治疗难治性非霍奇金淋巴瘤疗效满意 ,不良反应较轻 ,安全可靠。
Objective To observe the efficacy of BVMAP regimen in the treatment of refractory non-Hodgkin’s lymphoma. Methods Bleomycin 10 mg/m2 was injected intramuscularly on the 1st, 3rd, and 5th days; Changchun Dixin 3 mg/m2, intravenous drip on the 1st and 8th days; methotrexate 120 mg/m2, intravenous drip, on the 1st 8 days; cytarabine 60 mg/m2, intravenous drip, 1 to 5 days; prednisone (PDN) 30 mg/m2, orally, 1 to 14 days. 28 days for 1 cycle, continuous medication over 2 cycles to evaluate efficacy. Results There were 20 cases in the whole group, 5 cases of CR, 7 cases of PR, 6 cases of NC, 2 cases of PD, and the effective rate was 60%. The adverse reactions were mainly leukocyte and platelet decline with an incidence of 90% and 50%, respectively. Conclusion The efficacy of BVMAP regimen in the treatment of refractory non-Hodgkin’s lymphoma is satisfactory, and the adverse reactions are mild and safe.