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以心阻抗血流图测定麻醉犬的心输出量及心缩时间间距,同时测定动脉血压,观察了山莨菪碱对犬血流动力学和心泵功能的影响。山莨菪碱5mg/kg wt,iv后5～10min,平均动脉压和总外周阻力有显著下降(两者P<0.001),心率和心输出量也有一定程度的减少(两者分别为P<0.002和P<0.05):Q-Z间期延长(P<0.05),Heather指数降低(P<0.05),PEP/LVET增大(P<0.02),与给药前的对照状况相比差异有高度显著性或显著性。给药后60～90min上述指标大致恢复到对照水平。结果表明:山莨菪碱在扩张血管、降低总外周阻力、降低动脉血压的同时,还降低心脏的泵血功能。
Cardiac output and cardiac time were measured by impedance cardioplegia in anesthetized dogs. Arterial blood pressure was measured at the same time. The effects of anisodamine on hemodynamics and cardiac pump function were observed. Anisodamine 5mg / kg wt, iv 5 ~ 10min, mean arterial pressure and total peripheral resistance were significantly decreased (both P <0.001), heart rate and cardiac output also decreased to a certain extent (P <0.002 (P <0.05). The QZ interval was prolonged (P <0.05), Heather index was decreased (P <0.05), PEP / LVET was increased (P <0.02), which was significantly higher than that before administration Or significance. 60 ~ 90min after administration of the above indicators returned to the control level. The results showed that: Anisodamine in the expansion of blood vessels, reducing the total peripheral resistance, reduce arterial blood pressure, but also reduce the heart pump function.