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本文报道测定纤溶酶原活力对诊断病毒性肝炎的价值。对象为急性病毒性肝炎病人447例,其中轻型136例,中型163例,重型120例,急性肝坏死28例;肝硬化32例;阻塞性黄疸140例,其中胆囊结石37例、恶性肿瘤25例、其它78例。病毒性肝炎每间隔7天,急性肝坏死每间隔4~24小时测定1次纤溶酶原活力。同时检验了血清胆红素含量、麝香草酚试验、血凝固试验、谷丙转氨酶活力。用微量血凝圃法测得10~60岁健康人100名,其纤溶酶原活力为83~126%(平均值为104%);1岁以下儿童17名为81~141%(平均值为111%)。结果病毒性肝炎急性期纤溶酶原活力下降。肝炎越重、检验越早,其活力下降越多。急性肝坏死纤溶酶原活力平均值是11%,轻型病毒性肝炎是81%。每周1次的检查发现纤溶酶原下降的频数逐渐减少。
This article reports the determination of the activity of plasminogen in the diagnosis of viral hepatitis. The subjects were 447 patients with acute viral hepatitis, of which 136 were light, 163 were medium, 120 were heavy, 28 were acute hepatic necrosis, 32 were cirrhosis, 140 were obstructive jaundice. Among them, 37 were gallstone and 25 were malignant , The other 78 cases. Viral hepatitis every 7 days, acute hepatic necrosis every 4 to 24 hours to determine a plasminogen activity. At the same time test the serum bilirubin, thymol test, blood coagulation test, alanine aminotransferase activity. 100 healthy people aged 10-60 years were measured by micro-hemagglutination test, and their plasminogen activity was 83-126% (mean was 104%); 17 children under 1 year old were 81-141% (average 111%). Results The acute phase of viral hepatitis decreased plasminogen activity. The heavier hepatitis, the earlier the test, the more their vitality decreased. Acute liver necrosis The average of plasminogen activity was 11%, light-type viral hepatitis was 81%. Weekly examination found that the decline in the number of plasminogen gradually reduced.