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目的研究丙丁酚对高脂高胆固醇饲养的载脂蛋白E基因敲除小鼠和C57BL6/J小鼠血脂及动脉粥样硬化病变的影响,以及肝脏B类I型清道夫受体和PPARγ表达的变化。方法分别随机将20只载脂蛋白E-/-小鼠和20只C57BL6/J小鼠分为载脂蛋白E-/-高脂组和载脂蛋白E-/-高脂+0.5%丙丁酚组。动物喂
Objective To investigate the effects of probucol on serum lipids and atherosclerosis in high-fat and high cholesterol-fed apolipoprotein E knockout mice and C57BL6 / J mice and the expression of liver type B type I scavenger receptor and PPARγ Variety. Methods Twenty apolipoprotein E - / - mice and 20 C57BL6 / J mice were randomly divided into apolipoprotein E - / - high fat group and apolipoprotein E - / - high fat + 0.5% probucol group. Animal feed