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乙双吗啉为我国首先合成的抗癌药，长期服用可诱发白血病．为进一步研究其遗传毒性的机理，本研究应用胞质分裂阻滞法（CB法）研究了乙双吗啉对体外培养人淋巴细胞微核形成及细胞动力学的效应．实验结果表明，乙双吗啉在胞质分裂阻滞的双核细胞及未阻滞的单核细胞中，均诱发微核形成并呈剂量依赖性增加；同时乙双吗啉具有明显的细胞毒性，抑制细胞分裂，双核与多核细胞率呈现剂量依赖性下降，可见，乙双吗啉是一个诱变与细胞毒因子．同时本文还讨论了CB－MNT实用价值的问题．
B double morpholine for our first synthetic anti-cancer drugs, long-term use can induce leukemia. In order to further study the mechanism of its genotoxicity, this study studied the effect of betablastine on the micronuclei formation and cytokine in human lymphocytes cultured in vitro by using the cytokinin block method (CB method). The experimental results show that B Bmorph morphine induces micronucleus formation and increases in a dose-dependent manner in cytokinesis-arrested binucleated cells and non-blocked monocytes, meanwhile B-morphine has obvious cytotoxicity, Inhibition of cell division, binucleated and multinucleated cells rate showed a dose-dependent decline, we can see that Bimemorph is a mutagenesis and cytotoxic agents. At the same time, this article also discusses the practical value of CB-MNT.