论文部分内容阅读
目的通过Meta分析探讨信号转导和转录激活因子4(STAT4)基因rs7574865位点单核苷酸多态性(SNP)与系统性红斑狼疮(SLE)易感性之间的关系。方法两名研究者分别检索Pub Med、Web of science、Scopus、中国知网和万方数据库,筛选出相关文献。用合并OR值和95%CI评价STAT4 rs7574865位点SNP与SLE易感性之间的关系。结果共纳入27篇研究,包含21 902例SLE患者和37 780例对照。Meta分析结果如下:等位基因模型(T vs G,OR=1.56,95%CI:1.49~1.63),纯合子模型(TT vs GG,OR=2.32,95%CI:2.08~2.58),杂合子模型(TG vs GG,OR=1.52,95%CI:1.41~1.64),显性遗传模型(TT/TG vs GG,OR=1.67,95%CI:1.55~1.79),隐性遗传模型(TT vs TG/GG,OR=1.83,95%CI:1.65~2.02)。按研究对象所在的地区进行亚组分析后显示,所有亚组中,rs7574865 SNP均与SLE易感性有关。结论 STAT4 rs7574865位点SNP与SLE的易感性有关,T等位基因的存在增加SLE的患病风险。
Objective To investigate the relationship between SNP rs7574865 SNP and susceptibility to systemic lupus erythematosus (SLE) by Meta-analysis. Methods Two researchers searched PubMed, Web of science, Scopus, CNKI and Wanfang database respectively to screen out relevant literature. The combined odds ratio (OR) and 95% CI were used to evaluate the relationship between the SNP of STAT4 rs7574865 and SLE susceptibility. Results A total of 27 studies were included, including 21,902 SLE patients and 37,780 controls. The results of meta-analysis were as follows: allele model (T vs G, OR = 1.56, 95% CI: 1.49-1.63), homozygous model (TT vs GG, OR = 2.32, 95% CI: 2.08-2.58) (TT vs TG vs GG, OR = 1.67, 95% CI: 1.55 to 1.79), and the recessive hereditary model (TT vs TG, GG, OR = 1.52, 95% CI: 1.41-1.64) TG / GG, OR = 1.83, 95% CI: 1.65-2.02). A subgroup analysis of the region of study showed that in all subgroups, rs7574865 SNP was associated with SLE susceptibility. Conclusion The SNP of STAT4 rs7574865 is associated with the susceptibility to SLE. The presence of T allele increases the risk of SLE.