论文部分内容阅读
目的:观察稳消Ⅱ方对动脉粥样硬化模型兔脂质代谢的影响,探讨其防治动脉粥样硬化的作用机制.方法:将38只健康新西兰大白兔随机分为空白组9只和造模组29只.空白组子标准饲料,造模组予高脂饲料喂养8周,第8周末随机处死2只.造模成功后随机分为稳消Ⅱ方干预组(9只)、辛伐他汀对照组(9只)、模型对照组(9只),并改用标准饲料喂养.分别予相应药物灌胃干预8周[模型对照组与空白对照组均予生理盐水10 mL/(kg·d)].分别于第0、8、16周末进行耳缘静脉采血,检测TC、TG、HDL-C、LDL-C、ALT、AST、Cr、BUN、UA、CK水平.结果:稳消Ⅱ方干预组、辛伐他汀对照组TC、TG、LDL-C水平均低于模型对照组,HDL-C水平高于模型对照组,差异均有统计学意义(P＜0.05).稳消Ⅱ方干预组、辛伐他汀对照组与空白对照组比较,TC、TG水平差异均无统计学意义(P＞0.05);稳消Ⅱ方干预组、辛伐他汀对照组LDL-C、HDL-C水平高于空白对照组,差异有统计学意义(P＜0.05).稳消Ⅱ方干预组与辛伐他汀对照组比较,TC、TG、LDL-C、HDL-C水平差异均无统计学意义(P＞0.05).稳消Ⅱ方组、辛伐他汀组干预前后自身对照比较,TC、LDL-C、TG水平均显著下降,HDL-C水平明显上升,差异均有统计学意义(P＜0.05).结论:稳消Ⅱ方可降低动脉粥样硬化兔TC、TG、LDL-C,升高HDL-C水平,调节脂质代谢,改善和延缓动脉粥样硬化,且其对实验兔ALT、AST、Cr、BUN、UA、CK无不良影响.“,”Objective:To observe the effect of different doses of Wenxiao Ⅱ decoction on lipid metabolism in experimental atherosclerosis rabbits,and to explore its mechanism in treating atherosclerosis.Methods:The 38 New Zealand rabbits were randomly divided into two groups according to the weight:the blank control group with 9 rabbits and the model group with 29 rabbits,regardless of male or female.Except for those in the blank group,all rabbits were fed with a high-cholesterol diet.After 8 weeks,two rabbits randomly from the model group were killed to confirm whether the model is successful or not.Then,the model group was randomly divided into three groups:Wenxiao Ⅱ decoction group,simvastatin group and model control group,fed with standard diet rather than the high-fat diet.Give the corresponding medication orally 8 weeks [blank control group and model control group feed with 0.9％ NS 10 mL(kg·d)].Respectively,to test TC,TG,HDL-C,LDL-C,ALT,AST,Cr,BUN,UA,CK levels on the 0,8,16 weekend through the ear vein blood collection.Results:Compared with the model group,TC,TG and LDL-C levels were significantly lower while HDL-C levels increase a lot in Wenxiao Ⅱ decoction group and simvastatin group,of which has meaningful statistics significance (P＜0.05).Compared with the blank control group,TC,TG levels of both Wenxiao Ⅱ decoction group and simvastatin group has no statistical difference (P＞0.05).LDL-C,HDL-C levels decreased,and statistically significant (P＜0.05).Compared with the simvastatin group,the TC,TG and LDL-C,HDL-C levels of Wenxiao Ⅱ decoction group were not significantly different (P＞0.05).The levels of TC,LDL-C and TG decreased apparently,and the level of HDL-C increased significantly after treatments both in Wenxiao Ⅱ decoction group and simvastatin group,and there was statistical difference (P＜0.05).Conelusion:Wenxiao Ⅱ decoction can reduce TC,TG,LDL-C,increased HDL-C levels,regulate lipid metabolism effect,and prevent the occurrence of atherosclerosis.