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目的探讨还原型谷胱甘肽对慢性阻塞性肺疾病急性加重期(AECOPD)炎性细胞因子的影响。方法慢性阻塞性肺疾病急性加重患者随机分为两组,治疗组在综合治疗基础上加用应用还原型谷胱甘肽,对照组为综合治疗,治疗前后观察血清细胞因子(IL-8、TNF-α、IL-6)变化。结果两组治疗后均能降低血清TNF-α、IL-8、IL-6的表达,且治疗组优于对照组。结论还原型谷胱甘肽能降低AECOPD患者血清中IL-8、TNF-α、IL-6表达。
Objective To investigate the effect of reduced glutathione on inflammatory cytokines in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into two groups. The treatment group was treated with reduced glutathione on the basis of comprehensive treatment, while the control group was treated comprehensively. Serum cytokines (IL-8 and TNF -α, IL-6). Results After treatment, the serum levels of TNF-α, IL-8 and IL-6 in both groups were significantly lower than those in the control group. Conclusions Reduced glutathione can reduce the serum levels of IL-8, TNF-α and IL-6 in AECOPD patients.