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本文应用角膜内皮显微镜对88眼术后透明的穿透角膜移植片内皮细胞进行研究分析,受者年龄范围在11～63岁之间。第一组包括47个植片(供者年龄在10岁以下,平均2.3岁);第二组41个植片(供者年龄在10岁以上,平均28.7岁)。结果表明,88例植片术后内皮密度变化与供者年令、死亡至手术时间、手术后时间都存在着负相关关系。植片内皮细胞数减少主要发生在木后一年内,术后3个月时减少27.0%,1年时减少40.9%,1～4年时减少11.6%,手术4年以后植片内皮密度即趋恒定而达到内环境相对稳定状态。幼年供眼组植片内皮损失率与文献所提相似。本文资料亦表明幼年供眼植片术后可保持相当高的内皮细胞密度,这种情况至少保持一年。将两组植片作比较,术后3个月内和术后3月至1年内植片内皮细胞平均密度差别均有高度显著性(t 检验分别为 P<0.001,P<0.005),而手术1年以后两组植片平均内皮细胞密度差别无显著性。对两组植片内皮细胞作多形性形态学分析,提示两组植片各类细胞百分比差别均无显著性,但同一组内植片六边形细胞与其他细胞的百分比之间却存在着明显负相关关系。
In this paper, corneal endothelium microscopy was used to analyze the transparent penetrating corneal endothelial cells in 88 eyes. The age range of recipients was between 11 and 63 years old. The first group consisted of 47 implants (donor age under 10 years, mean 2.3 years); the second group, 41 implants (donor age 10 years and older, mean 28.7 years). The results showed that there was a negative correlation between the change of endothelial density and the year of donor, the time from death to operation and the time after operation. The decrease in the number of endothelial cells in the grafts occurred within one year after transplantation, 27.0% at 3 months, 40.9% at 1 year, 11.6% at 1-4 years, and at 4 years after operation Constant and achieve a relatively stable environment. Juvenile ophthalmic group of endothelial loss rate and literature similar. The information in this paper also shows that maintaining the relatively high endothelial cell density in juvenile ophthalmic implants remains for at least one year. Comparing the two groups of implants, the average density of implanted endothelial cells within 3 months and 3 months to 1 year after operation were highly significant (t-test, P <0.001, P <0.005, respectively) After 1 year, there was no significant difference in average endothelial cell density between the two groups. Morphological analysis of pleomorphic endothelial cells in both groups showed that there was no significant difference in the percentages of various types of cells between the two groups, but there was a significant difference between the percentage of hexagonal cells and other cells in the same group Significant negative correlation.