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目的:观察过敏性紫癜(HSP)患儿可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)表达水平及瘀血状态,分析瘀血与尿中黏附分子及肾脏损伤的关系。方法:HSP患儿80例分为无肾损(NO-HSPN)组、血尿组、血尿加蛋白尿组,正常组(健康儿童10名)。根据中医瘀血症候积分表进行瘀血评分。ELISA法测定sICAM-1、sVCAM-1的表达水平。结果:①与NO-HSPN组比较,血尿加蛋白尿组瘀血积分明显升高(P<0.01)。②血清sICAM-1在各组中表达差异无统计学意义,尿sICAM-1在血尿加蛋白尿组明显增加,与正常组和NO-HSPN组比较差异有统计学意义(P<0.05,P<0.01)。③血清sVCAM-1在各组间表达差异无统计学意义,血尿加蛋白尿组尿sVCAM-1的表达水平明显高于其他3组。④血尿加蛋白尿组尿sICAM-1和sVCAM-1的表达与瘀血积分的评定呈正相关。结论:瘀血参与了HSP肾损害过程。血尿加蛋白尿组HSP患儿尿中sICAM-1、sVCAM-1显著增加。
Objective: To investigate the expression of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) and the status of blood stasis in children with Henoch-Schonlein purpura (HSP) Molecular and kidney damage. Methods: Eighty children with HSP were divided into three groups: NO-HSPN group, hematuria group, hematuria plus proteinuria group, and normal group (10 healthy children). According to TCM ecchymosis score table for stasis score. ELISA method sICAM-1, sVCAM-1 expression levels. Results: ① Compared with NO-HSPN group, the blood stasis score of hematuria plus proteinuria was significantly increased (P <0.01). ② There was no significant difference in the expression of sICAM-1 in each group, and urine sICAM-1 was significantly increased in hematuria and proteinuria group, and there was significant difference between normal group and NO-HSPN group (P <0.05, P < 0.01). ③ There was no significant difference in serum sVCAM-1 expression among the groups. The expression of sVCAM-1 in urine of urine and urine albumin group was significantly higher than the other three groups. ④ The urinary sICAM-1 and sVCAM-1 expression in hematuria and proteinuria group were positively correlated with the assessment of blood stasis score. Conclusion: Stasis is involved in the process of HSP renal injury. Urinary serum sICAM-1, sVCAM-1 in hematuria and proteinuria group were significantly increased.