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目的：观察急性心肌梗塞（AMI）患者抗凝血酶Ⅲ（AT－Ⅲ）和凝血酶抗凝血酶复合物（TAT）的变化特点及临床意义。方法；检测42例AMI患者AT－Ⅲ抗原、AT－Ⅲ活性、TAT水平，与30例健康对照组进行比较。分析吸烟等因素与这些指标的关系。结果：AMI组AT－Ⅲ抗原、活性、TAT水平分别为322±98mg／L，75．3％±26．7％，14．2±10．4μg／L。结论：AMI组AT－Ⅲ活性降低，TAT水平升高，提示AMI患者存在凝血激活；两者在AMI患者中的变化的意义可能不尽相同。
Objective: To observe the changes and clinical significance of antithrombin Ⅲ (AT-Ⅲ) and thrombin antithrombin complex (TAT) in patients with acute myocardial infarction (AMI). Methods; AT-Ⅲ antigen, AT-Ⅲ activity and TAT in 42 AMI patients were detected and compared with 30 healthy controls. Analysis of smoking and other factors and the relationship between these indicators. Results: AT-Ⅲ antigen, activity and TAT levels in AMI group were 322 ± 98 mg / L, 75.3% ± 26.7% and 14.2 ± 10.4 μg / L, respectively. CONCLUSION: AT-Ⅲ activity is decreased and TAT level is elevated in AMI patients, suggesting that there is coagulation activation in patients with AMI. The significance of the changes in AMI patients may not be the same.