论文部分内容阅读
采用图像分析技术定量分析胆管癌细胞与肝胆管结石所致胆管上皮不典型增生细胞核浆比值与核仁形成区相关蛋白的关系。结果显示：高、中、低分化胆管癌细胞与肝胆管结石胆管上皮单纯性增生细胞的核浆比值有显著性差异（Ｐ＜０．０１）；高分化与低分化胆管癌细胞核浆比值和嗜银核仁形成区相关蛋白计数有显著性差异（Ｐ＜０．０１）；但高分化胆管癌细胞与胆管上皮不典型增生细胞核浆比值无显著性差异（Ｐ＞０．０５）。由此提示，肝胆管结石所致胆管上皮增生可能是胆管癌的一种癌前病变。
Image analysis technique was used to quantitatively analyze the relationship between the ratio of nuclear to cytoplasm of biliary epithelial dysplasia and the associated protein in nucleolar formation area. The results showed that there were significant differences in the ratio of nuclear to pulp between the hyperplasia of high-, middle-, and poorly-differentiated cholangiocarcinoma cells and bile duct epithelial cells of hepatobiliary stones (P<0.01); the ratio of nuclear to cytoplasm of well-differentiated and poorly differentiated cholangiocarcinoma cells There was a significant difference in the number of associated proteins in the silver nucleolar formation area (P<0.01), but there was no significant difference in the ratio of the cytoplasm of highly differentiated cholangiocarcinoma cells to dysplasia of biliary epithelium (P>0.05). This suggests that biliary epithelial hyperplasia due to hepatolithiasis may be a precancerous lesion of cholangiocarcinoma.