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1985～1996年我们共诊治重度急性有机磷农药中毒98例,其中22例出现不同程度的肝脏功能损害。分析如下。1 临床资料1.1 一般资料 本组22例,男6例,女16例。意外中毒4例,蓄意服毒18例。单纯性肝损害15例,患慢性乙型肝炎合并急性中毒后出现急性肝损害7例。急性肝炎样表现者18例,表现为急性暴发性肝炎、肝坏死,并出现肝脏功能衰竭者4例,其中并发肝性脑病昏迷者2例,2例均合并有肾功衰竭和出血倾向。2例中经抢救治愈1例,死亡1例。1.2 临床表现与实验室检查 所有病人均在1～5周前有重度有机磷农药中毒史,并能排除其他原因所致的急性肝炎。7例既往患有慢性乙型肝炎,入院后检查测HBsAg均为强阳性反应。所有病人一旦发病,其临床症状和体征与急性
From 1985 to 1996, we treated 98 cases of severe acute organophosphorus pesticide poisoning, of which 22 cases showed different degrees of liver dysfunction. analyse as below. 1 Clinical data 1.1 General Information The group of 22 patients, 6 males and 16 females. Accidental poisoning in 4 cases, deliberately taking poison in 18 cases. Simple liver damage in 15 cases, suffering from chronic hepatitis B acute poisoning with acute liver injury in 7 cases. Acute hepatitis-like performance in 18 cases, manifested as acute fulminant hepatitis, liver necrosis, and liver failure in 4 cases, of which 2 cases of coma with hepatic encephalopathy, 2 patients were associated with renal failure and bleeding tendency. In 2 cases, 1 patient was cured and 1 patient died. 1.2 Clinical manifestations and laboratory tests All patients in the 1 to 5 weeks before the severe organophosphorus pesticide poisoning history, and can rule out other causes of acute hepatitis. Seven patients had chronic hepatitis B. Previously, HBsAg was strongly positive after admission. All patients once the onset, the clinical symptoms and signs and acute