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不对称的酮与羟胺作用时,生成的酮肟是顺式和反式酮肟的混合物.不同构型酮肟的稳定性与结构中的立体效应和电子效应有关.芳基乙酮肟的构型主要是反式.我们曾将苯基三氟乙酮肟(Ⅰ)、对-甲苯基三氟乙酮肟(Ⅱ)和对-甲氧苯基三氟乙酮肟(Ⅲ)进行Beckmann重排,分别得到一种重排产物——相应的三氟乙酰芳胺(ArNHCOCF_(?)).根据Beckmann重排是反式重排机理,我们认为Ⅰ、Ⅱ、Ⅲ与芳基乙酮肟相似,主要是反式构型Ar—C—CF_(?).为了确定顺式和反式构型之间的比例,我
Asymmetric ketones and hydroxylamine, the resulting ketoxime is a mixture of cis and trans ketoximes. The stability of different configurations of ketoximes is related to the stereoscopic and electronic effects in the structure. The structure of aryl ketoxime Type is mainly trans. We have phenyl trifluoroethanone oxime (Ⅰ), p-tolyl trifluoroacetatoxime (Ⅱ) and p-methoxyphenyl trifluoroacetonitroxime (Ⅲ) were Beckmann weight (ArNHCOCF_ (?)). According to Beckmann rearrangement is a trans rearrangement mechanism, we believe that Ⅰ, Ⅱ, Ⅲ and aryl ketoxime similar , Mainly the trans configuration Ar-C-CF_ (?). To determine the ratio between cis and trans configuration, I