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[目的]探讨环氧合酶‐2(COX‐2)蛋白和基质金属蛋白酶‐2( MMP‐2)在胃癌组织中的表达及其临床意义.[方法]采用 SP 免疫组织化学染色技术,检测60例胃癌石蜡组织和27例正常结肠组织中 COX‐2和MMP‐2的表达情况.[结果]COX‐2和 MMP‐2在胃癌组织中表达明显高于正常组织( P <0.01);MMP‐2和COX‐2表达在胃癌癌不同分化程度、Dukes 分期、淋巴结转移中差异明显( P <0.05),分化越低、分期越晚、发生淋巴结转移者表达越高;两种蛋白在结肠癌组织中的表达呈正相关( P <0.01).[结论]COX‐2与MMP‐2的表达,与胃癌的侵袭和转移密切相关,联合检测 COX‐2和 MM P‐2表达可能有助于判定胃癌临床病理特征及预后.“,”Objective] To explore the expression of cyclooxygenase(COX‐2) and matrix metalloproteinas‐es(MMP‐2) in gastric carcinoma and its clinical significance .[Methods]The expression of COX‐2 and MMP‐2 in 60 paraffin‐embedded tissues of gastric carcinoma and 27 normal colon tissues were detected by SP immuno‐histochemical method .[Results] The expression of COX‐2 and MMP‐2 in the tissues of gastric carcinoma was significantly higher than that in normal colon tissues (P < 0 .01) .There were significant differences in the ex‐pression of MMP‐2 and COX‐2 among different differentiation degrees ,Dukes stage and lymph node metastasis of gastric carcinoma( P < 0 .05) .The expression of COX‐2 and MMP‐2 was higher in low differentiation ,late stage and lymph node metastasis .The expression of COX‐2 had positive correlation with the expression of MMP‐2 in colon cancer( P < 0 .01) .[Conclusion]The expressions of COX‐2 and MMP‐2 are closely related with the invasion and metastasis of gastric carcinoma .The combination detection of COX‐2 and MMP‐2 may be helpful for the evaluation of clinicopathologic features and prognosis of gastric carcinoma .