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目的 :观察干扰素联合大剂量胸腺肽治疗慢性乙型肝炎的临床疗效。方法 :干扰素 3MU/次 ,肌肉注射 ,开始每日一次 ,连用 3 0天 ,后改为隔日一次 ,总疗程 90天。胸腺肽 10 0mg加 10 %葡萄糖注射液 2 5 0ml,静脉点滴 ,每日一次 ,总疗程 90天。A组干扰素 +胸腺肽治疗 ,B组单用干扰素 ,C组单用胸腺肽。结果 :疗程结束后A、B、C三组的完全应答分别为 2 0 ( 4 7 6)、8( 2 5 0 )、5( 16 1) ,A组与B、C组分别比较具显著差异 (P <0 0 5、P <0 0 1)。疗程结束半年后 ,A、B、C三组的完全应答分别为 18( 4 2 9)、7( 2 1 9)、4( 12 9)。A组与B、C组分别比较具有显著性差异 (P <0 0 5、P <0 0 1)。结论 :干扰素联合大剂量胸腺肽治疗慢性肝炎较单用干扰素或胸腺肽有较好的临床疗效
Objective: To observe the clinical efficacy of interferon combined with high-dose thymosin in the treatment of chronic hepatitis B. Methods: interferon 3MU / time, intramuscular injection, once a day, once every 30 days, later changed to every other day, the total duration of 90 days. Thymosin 10mg plus 10% glucose injection 250ml, intravenous drip, once daily, the total course of 90 days. A group of interferon + thymosin treatment, B group with interferon, C group with thymosin alone. Results: The complete responses in groups A, B and C after the treatment were 20 (476), 8 (250) and 5 (161) respectively. There was significant difference between group A and group B and group C (P <0 05, P <0.01). Six months after the end of treatment, the complete response in groups A, B, and C was 18 (4 2 9), 7 (2 1 9), 4 (12 9), respectively. There was significant difference between group A and group B and C (P <0.05, P <0.01). Conclusion: Interferon combined with high-dose thymosin in the treatment of chronic hepatitis than interferon or thymosin alone has a good clinical effect