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目的观察奥美拉唑、左氧氟沙星及克拉霉素三联治疗十二指肠溃疡幽门螺杆菌(Hp)的临床疗效。方法170例幽门螺杆菌(Hp)阳性消化性溃疡患者,随机分为治疗组及对照组。治疗组84例,即口服奥美拉唑20mg、左氧氟沙星200mg及克拉霉素500mg,均为2次/d,疗程1周;对照组86例,即口服奥美拉唑20mg、阿莫西林1000mg及甲销唑400mg,均为2次/d,疗程1周。1周后两组继续服用奥美拉唑20mg,2次/d,连服4周,各组疗程结束后1个月复查胃镜。观察Hp根除率、溃疡愈合率,观察症状缓解率及不良反应等,治疗效果评定标准。结果治疗组与对照组Hp根除率分别为88.1%(74/84)62.8%(54/86),溃疡总愈合率分别为85.7%(58/84)、72.1%(52/86),副反应发生率分别为14.3%(12/84)、23.3%(20/86),差异均无显著性(P>0.05)。结论奥美拉唑、左氧氟沙星及克拉霉素三联组有较理想的Hp感染根除率及溃疡愈合率,为治疗Hp阳性消化性溃疡的较好方法之一,且副反应发生率低。
Objective To observe the clinical efficacy of omeprazole, levofloxacin and clarithromycin triple therapy for Helicobacter pylori (Hp) in duodenal ulcer. Methods 170 patients with Helicobacter pylori (Hp) -positive peptic ulcer were randomly divided into treatment group and control group. The treatment group of 84 patients, that is oral omeprazole 20mg, 200mg of levofloxacin and clarithromycin 500mg, were 2 times / d, treatment for 1 week; control group of 86 patients, that is, oral omeprazole 20mg, amoxicillin 1000mg and Fentuzole 400mg, are 2 times / d, treatment for 1 week. After 1 week, the two groups continued to take omeprazole 20mg, 2 times / d, and even served for 4 weeks, each group after the end of 1 month review gastroscopy. Hp eradication rate, ulcer healing rate, observation of symptom relief rate and adverse reactions were observed, and the therapeutic effect was evaluated. Results The eradication rates of Hp in treatment group and control group were 88.1% (74/84) 62.8% (54/86), 85.7% (58/84) and 72.1% (52/86) The incidence rates were 14.3% (12/84) and 23.3% (20/86) respectively, with no significant difference (P> 0.05). Conclusions Omeprazole, levofloxacin and clarithromycin triple group have better Hp infection eradication rate and ulcer healing rate, which is one of the better ways to treat Hp positive peptic ulcer with low incidence of side effects.