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在发达国家由于广泛实行免疫计划,已基本消灭白喉和破伤风。免疫接种使白喉杆菌产毒株的传播大为减弱。尽管如此,在某些免疫接种率很高的国家仍有白喉爆发的报告,这是由于部分成人抗毒素含量低于最低保护水平0.01IU/ml。 作者评估了意大利不同地区青年人群中对破伤风和白喉无保护力的比例。 从来自意大利各地区17～22岁的新兵采取血清标本。白喉抗毒素的评估方法是:制备0.1ml被检血清和0.1ml毒素混合物及另1份0.1ml标准白喉抗毒素与毒素混合物。室温培育60分钟后,把两个混合物皮内接种于成年白兔。48小时后,测被检血清组
Diphtheria and tetanus have been basically eliminated in developed countries as a result of the widespread immunization program. Vaccination has greatly reduced the spread of strains of diphtheria toxigenic strains. In spite of this, there are reports of diphtheria outbreaks in some countries with high rates of immunization, as some adult antitoxin levels are below the minimum level of protection of 0.01 IU / ml. The authors evaluated the proportion of unprotected tetanus and diphtheria among young people in different parts of Italy. Serum samples were collected from recruits 17 to 22 years old from all over Italy. Diphtheria antitoxin is evaluated by preparing a mixture of 0.1 ml sera and 0.1 ml toxin and another 0.1 ml standard diphtheria antitoxin toxin mixture. After incubation for 60 minutes at room temperature, both mixtures were inoculated intradermally in adult white rabbits. After 48 hours, the serum was tested