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目的:评价含呋喃唑酮三联方案不同疗程治疗幽门螺杆菌的有效性和安全性。方法:将幽门螺杆菌阳性患者随机分成左氧氟沙星组、阿莫西林组和对照组,按疗程再分成亚组,治疗组均包含呋喃唑酮和奥美拉唑,观察其疗效。结果:含呋喃唑酮三联方案与对照组在总根除率上无差异,且随疗程增加而增加;不良反应发生率各组随疗程增加而增加,左氧氟沙星组总发生率要略高于其他组;在临床症状缓解上,3组间无差异,各组缓解率随疗程增加而增加。结论:含呋喃唑酮三联方案是安全有效的幽门螺杆菌根除方案,10,14日疗程均可获得好的疗效,10日疗程最佳。
OBJECTIVE: To evaluate the efficacy and safety of furazolidone-based triple regimen in the treatment of Helicobacter pylori. Methods: Helicobacter pylori positive patients were randomly divided into levofloxacin group, amoxicillin group and control group. The patients were subdivided into subgroups according to the course of treatment. Furazolidone and omeprazole were included in the treatment group, and the curative effect was observed. Results: There was no difference in the total eradication rate between furazolidone-containing triple regimen and control group, and with the increase of course of treatment, the incidence of adverse reactions increased with the course of treatment, and the total incidence of levofloxacin group was slightly higher than that of other groups. Mitigation, no difference between the three groups, the remission rate increased with the course of treatment increased. Conclusion: The triple regimen containing furazolidone is a safe and effective eradication program for Helicobacter pylori, and good curative effect can be obtained on the 10th and 14th days with the best treatment on the 10th.