CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p1

• 作 者: Wenqi Du Zongxiang Liu Wentao
• 机 构: DepartmentofPathology,DepartmentofAnatomy,DepartmentofPeriodontalMucosalDiseases,DepartmentofGeneral
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2019年3期
• 关键词: CSN6 GASTRIC cancer proliferation p16 REGγ
• 基金项目: supported by the National Natural Science Foundation of China(Grant No.81572349,81872080),Jiangsu Provincial Medical Talent(Grant No.ZDRCA2016055),the Science and Technology Department of Jiangsu Prov

Objective: CSN6 is a vital subunit of the constitutive photomorphogenesis 9(COP9) signalosome(CSN), which is responsible for development disorders and promotes ubiquitin-26 S proteasome-dependent degradation in vitro and vivo.Its role in the tumor develop