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目的探讨甘精胰岛素联合格列美脲治疗2型糖尿病患者的临床效果。方法选取2013年5月至2015年11月大石桥市中心医院收治的89例2型糖尿病患者作为研究对象,根据治疗方式将其分为甘精胰岛素组(44例)和联合用药组(45例),比较两组患者治疗效果。结果治疗后,联合用药组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白(Hb Alc)均明显低于甘精胰岛素组,差异均有统计学意义(均P<0.05);联合用药组患者的不良反应发生率明显低于甘精胰岛素组,差异有统计学意义(χ2=8.415,P<0.05);治疗后,联合用药组患者生理领域、心理领域、独立性领域、社会关系领域、环境领域、精神支柱评分均明显高于甘精胰岛素组,差异均有统计学意义(均P<0.05);联合用药组患者治疗总满意明显高于甘精胰岛素组,差异有统计学意义(P<0.05)。结论甘精胰岛素联合格列美脲治疗2型糖尿病临床效果显著,能够有效控制血糖水平,降低不良反应发生风险,改善患者生命质量。
Objective To investigate the clinical effects of glargine and glimepiride in the treatment of type 2 diabetic patients. Methods Eighty-nine patients with type 2 diabetes who were treated in Dashiqiao Central Hospital from May 2013 to November 2015 were selected and divided into glargine group (n = 44) and combination group (n = 45) ), The treatment effect of two groups were compared. Results After treatment, fasting blood glucose, postprandial 2-hour postprandial blood glucose, and HbAc in patients in combination group were significantly lower than those in insulin-glargine group (all P <0.05); patients in combination group (Χ2 = 8.415, P <0.05). After treatment, the incidence of adverse reactions in the combination group was significantly lower than that in the insulin glargine group (χ2 = 8.415, P <0.05) (P <0.05). The total satisfaction of patients in combination therapy group was significantly higher than that of insulin glargine group (P <0.05), and the difference was statistically significant (P < 0.05). Conclusion Glargine and glimepiride treatment of type 2 diabetes clinical effect is significant, can effectively control blood sugar levels, reduce the risk of adverse reactions, improve patient quality of life.