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检测了41例急、慢性白血病(AL,CL)和27例骨髓增生异常综合症(MDS)病人血清唾液酸(SA)浓度水平及阳性率,并与慢性再生障碍性贫血(CAA)病人比较,发现AL,CL病人的SA水平,较CAA病人及正常人显著增高,上述各组病人的阳性率分别为83.8%,60.0%,14.3%,0%,AL病人SA水平又明显高于CL并与病情变化有关,经治疗完全缓解(CR)病人血清SA水平明显降低,CR后血清SA水平与维持缓解时间有相关性。MDS病人血清SA明显高于正常人而低于AL病人,MDS及其亚型RA+RAS组、RAEB+RAEB-t+CMML组的阳性率分子为33.3%,20.0%,50.0%,结果显示,血清SA升高可能与疾病发生发展有关。血清SA的检测对疾病诊断与鉴别诊断,判断病情、疗效及预后判断均具有一定的临床价值。
The serum levels of sialic acid (SA) and the positive rate of 41 patients with acute and chronic leukemia (AL, CL) and 27 patients with myelodysplastic syndrome (MDS) were detected. Compared with patients with chronic aplastic anemia (CAA) The SA levels in patients with AL and CL were significantly higher than those in patients with CAA and normal controls. The positive rates of SA in patients with AL and CL were 83.8%, 60.0%, 14.3% and 0%, respectively. The SA levels in patients with AL were significantly higher than those in patients with CL Serum SA levels were significantly decreased in patients with complete remission (CR) after treatment, and serum SA levels correlate with the duration of remission after CR. The serum SA of patients with MDS was significantly higher than that of normal patients, but lower than that of patients with AL. The positive rates of MDS and RA + RAS were 33.3%, 20.0% and 50.0% in RAEB + RAEB-t + CMML group, Elevated serum SA may be related to the development of the disease. Serum SA detection of disease diagnosis and differential diagnosis to determine the condition, efficacy and prognosis have some clinical value.