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目的:研究腺苷蛋氨酸对黄疸型病毒性肝炎的治疗作用。方法:选择血清总胆红素(STB)大于85.5μmol/L的病毒性肝炎152例,给予腺苷蛋氨酸(思美泰,德国基诺药厂生产)0.5g每日2次静脉注射,对照组130例给予10％门冬氨酸钾镁20ml/日静脉滴注,疗程2～4周,比较治疗前后症状、体征、STB、ALT、AST、GGT、PTA、白蛋白(ALB)、球蛋白(GLO)变化及住院天数,并观察心电图、血常规、BUN、Cr等。结果:恶心、呕吐、肝区痛、皮肤瘙痒、肝脾大的好转率两组相似,乏力、纳差、腹胀的好转率治疗组明显优于对照组(x~2检验P<0.05);肝功能比较,治疗组治疗后STB、ALT、AST下降幅度及复常率,PTA复常率均明显大于对照组(P<0.05或0.01),两组病人住院天数比较,治疗组较对照组明显缩短。治疗期间,不良反应率低,无骨髓、心肾方面的副作用。结论:思美泰能增强肝脏解毒功能,促进胆汁排泄,从而迅速改善病毒性肝炎的临床症状及肝功能,缩短了住院天数,且安全易行。
Objective: To study the therapeutic effect of adenosine methionine on jaundice virus hepatitis. Methods: Fifty-two patients with viral hepatitis with serum total bilirubin (STB) greater than 85.5 μmol / L were given 0.5 g of adenosyl methionine (Smectite, manufactured by Kenuo Pharmaceutical Factory, Germany) twice a day for intravenous injection and 130 Cases were given 10% potassium and magnesium aspartate 20ml / day for 2 ~ 4 weeks. The symptoms, signs, STB, ALT, AST, GGT, PTA, ALB, GLO ) Changes and hospitalization days, and observed electrocardiogram, blood, BUN, Cr and so on. Results: Nausea, vomiting, liver pain, pruritus, and improvement rate of hepatosplenomegaly were similar between the two groups. The improvement rate of fatigue, anorexia and abdominal distention in the treatment group was significantly better than that in the control group (P <0.05); Compared with the control group, the decrease of STB, ALT and AST and the rate of normalization and PTA of the treatment group were significantly greater than those of the control group (P <0.05 or 0.01). Compared with the control group, the treatment group was significantly shorter . During treatment, the adverse reaction rate is low, no bone marrow, heart and kidney side effects. Conclusion: Simei Thai can enhance the liver detoxification function and promote bile excretion, thereby rapidly improving the clinical symptoms and liver function of viral hepatitis, shorten the length of stay, and safe and easy.