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应用激光多普勒血流仪测定大鼠吸烟前后腰髓血流的变化。２８只ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠被随机均分成两组：吸烟组和非吸烟组。局部腰髓血灌流量的平均值在吸烟组为３５０．７±３２．７ＰＵ，明显高于非吸烟组均值２６４．６±１７．１ＰＵ，增加了３２．５１％（Ｐ值＜０．００１）。腰髓流动血细胞浓度在吸烟组平均为５１９．３±３２．４ＣＵ，非吸烟组为３５８．７±２９．１ＣＵ，增加了４４．７９％（Ｐ值＜０．００１）。但腰髓血流速度在吸烟后并不增加，反而下降了６．０４％。腰髓血流的上述变化与吸烟后动脉血压的变化无明显相关，推测上可能归因于吸烟对组织血流影响的部位差异性即机体对吸烟诱至的血管活性激素的复杂反应，或吸烟对血液内有形成分影响的病理生理反应。
Changes of lumbar cord blood flow before and after smoking in rats by laser Doppler flowmetry. Twenty-eight Sprague Dawley rats were randomly divided into two groups: smoking group and non-smoking group. The average value of local lumbar spinal blood perfusion was 350.7 ± 32.7 PU in the smoker group, significantly higher than that of the non-smoker group (264.6 ± 17.1 PU), an increase of 32.51% (P <0.001) . The density of circulating blood cells in the lumbar cord was 519.3 ± 32.4CU in the smoking group and 358.7 ± 29.1CU in the non-smoking group, an increase of 44.79% (P <0.001). However, lumbar cord blood flow did not increase after smoking, but decreased by 6.04%. There was no significant correlation between these changes of lumbar cord blood flow and changes of arterial blood pressure after smoking. It is speculated that this may be attributed to the difference of site of smoking on tissue blood flow, that is, the complex reaction of the body to vasoactive hormone induced by smoking or smoking Pathophysiology of the impact on the physical components of the blood.