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目的观察玻璃酸钠联合普拉洛芬对苯扎氯铵诱导新西兰兔干眼的治疗作用。方法使用0.25%苯扎氯铵滴眼液复制新西兰兔干眼模型,选择75只制作成功的动物模型随机分为3组。A组为空白对照组,不做任何处理;B组为单纯玻璃酸钠组,给予0.1%玻璃酸钠滴眼液,每天4次;C组为玻璃酸钠联合普拉洛芬组,给予0.1%玻璃酸钠滴眼液+普拉洛芬滴眼液,每天4次。观察D0、D3、D7、D14时的角膜荧光染色评分、泪膜破裂时间、泪液分泌等指标并进行统计分析。结果干预前各组间荧光染色评分、泪膜破裂时间、泪液分泌结果差异无统计学意义(P>0.05),具有可比性;干预后第7天及第14天,B组及C组各项观察指标均优于A组(P<0.05);C组较B组改善更为明显,差异有统计学意义(P<0.05)。结论玻璃酸钠联合普拉洛芬可以有效改善苯扎氯铵导致的新西兰兔的干眼症状。
Objective To observe the therapeutic effect of sodium hyaluronate combined with pranoprofen on benzalkonium chloride induced dry eye of New Zealand rabbits. Methods New Zealand rabbit dry eye model was reproduced with 0.25% benzalkonium chloride eye drops. Seventy-five animal models were selected and randomly divided into three groups. Group A is a blank control group, without any treatment; Group B is simple sodium hyaluronate group, given 0.1% sodium hyaluronate eye drops 4 times a day; Group C is sodium hyaluronate combined with pranoprofen group, given 0.1 % Sodium Hyaluronate Eye Drops + Pranoprofen Eye Drops 4 times a day. D0, D3, D7, D14 corneal fluorescence staining score, tear film rupture time, tear secretion and other indicators and statistical analysis. Results There was no significant difference in the scores of fluorescence staining, tear film rupture time and tear secretion between the groups before intervention (P> 0.05). On the 7th day and the 14th day after intervention, all the items of group B and group C The observation indexes were better than that of group A (P <0.05). The improvement of group C was more obvious than that of group B, the difference was statistically significant (P <0.05). Conclusion Sodium hyaluronate combined with pranoprofen can effectively improve the symptoms of dry eye caused by benzalkonium chloride in New Zealand rabbits.