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硒(Se)是人体的必须微量元素并且机体缺乏硒的临床地位已经被确立。人体主要从食物中获取硒,近期研究发现澳大利亚人群食物中硒元素水平有所下降。鉴于目前澳大利亚人群硒状态的数据有限,本研究的目的是测定澳大利亚人群血浆中元素硒的含量和一个能很好的反映硒状态的生物标记——谷胱甘肽过氧化物酶(GSH-Px)的活力,并且调查性别、年龄和心血管病(CVD)的发生对体内硒状态的影响。检测140例健康人(平均年龄54岁,年龄20～86岁)和112例(平均年龄67岁,40～87岁)CVD患者血浆中的Se浓度和GSX-Px活性。结果显示:健康澳大利亚人的血浆中硒的平均浓度为(100.2±1.3)μg/L、GSH-Px活性为(108.8±1.7)mol/L。虽然血浆中Se浓度的平均值达到GSH-Px最佳活性(Se 100μg/L)所需要的水平,但被检人群的47%的健康人低于此水平。进一步的评估显示某些年龄组人群是处于低Se状态的,尤其是在年龄大于81岁的群体中,女性Se=(97.6±6.1)μg/L,男性Se=(89.4±3.8)μg/L,不同性别的人群Se状态没有显著差异。除了年龄大于81岁的年龄组伴随心血管病的发生出现Se状态减少[血浆Se:正常人为(93.5±3.6)μg/L,CVD患者为(88.2±5.3)μg/L;血浆GSH-P_X活性:正常人为(98.3±3.9)U/L,CVD患者为(87.0±6.5)U/L)]外,其他年龄组人群CVD的存在对Se状态没有影响。这些结果强调了饮食中摄入适量的Se对于维持老年人的健康尤其是心血管患者是非常重要的。
Selenium (Se) is an essential trace element of the human body and the body’s clinical status of lack of selenium has been established. The body mainly selenium from food, the recent study found that the Australian population selenium levels in food decreased. In view of the limited data on selenium status in current Australian populations, the aim of this study was to determine the level of elemental selenium in the plasma of Australians and a good biomarker of glutathione peroxidase (GSH-Px ), And investigated the effects of gender, age, and cardiovascular disease on selenium status in the body. Plasma concentrations of Se and GSX-Px were measured in 140 healthy subjects (mean age 54 years, 20-86 years of age) and 112 (mean age 67 years, 40-87 years) CVD patients. The results showed that the average concentration of selenium in healthy Australian plasma was (100.2 ± 1.3) μg / L and the activity of GSH-Px was (108.8 ± 1.7) mol / L. Although the mean Se concentration in plasma reached the level required for optimal activity of GSH-Px (Se 100 μg / L), 47% of healthy subjects in the seizure population were below this level. Further evaluations showed that some age groups were at low Se status, especially in women older than 81 years (Se = (97.6 ± 6.1) μg / L for women and Se = (89.4 ± 3.8) μg / L for men There was no significant difference in Se status between groups of different sexes. Plasma Se: normal (93.5 ± 3.6) μg / L and (88.2 ± 5.3) μg / L for CVD patients; plasma GSH-P_X activity was observed in all patients except those older than 81 years old with cardiovascular disease : (98.3 ± 3.9) U / L in normal controls and (87.0 ± 6.5) U / L in CVD patients). The presence of CVD in other age groups had no effect on Se status. These results underscore the importance of adequate intake of Se in the diet to maintain the health of the elderly, especially in patients with cardiovascular disease.