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目的 :通过动物实验比较托吡酯 (妥泰 )与传统抗痫药的抗痫作用。方法比较观察三种剂量的托吡酯与 1～ 2种传统抗痫药对最大电休克发作试验 ,戊四唑发作阈值试验 ,印防已毒素发作试验 ,士的宁发作试验的作用。结果 :大中剂量的托吡酯对最大电休克发作试验、戊四唑发作阈值试验、印防已毒素发作试验有效 ,但效果不如传统药物。结论 :托吡酯是一种作用广泛的抗痫新药 ,但作为单独用药或首选用药还需临床进一步论证。
OBJECTIVE: To compare the anti-epileptic effects of topiramate (Topiramate) and traditional antiepileptic drugs through animal experiments. Methods The effects of three doses of topiramate and one or two traditional antiepileptic drugs on maximal electroshock attack, threshold test of pentylenetetrazol, onset of toxin poisoning test and strychnine seizure test were compared. Results: Large and medium doses of topiramate on the maximum electroshock attack test, pentylenetetrazol attack threshold test, printed anti-toxins attack test is effective, but the effect is not as good as traditional drugs. Conclusion: Topiramate is a new anti-epileptic drug with a wide range of effects. However, further clinical evidence is needed as a single drug or first-line drug.