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器官缺血再灌注损伤(IRI)可引起急慢性的器官功能功能衰竭甚至机体死亡。臭氧作为一种具有抗炎、增加组织氧供、改善微循环等作用的不稳定化学物质,可能在防治IRI上具有重要作用。近年来的研究显示,臭氧心脏缺血预处理和后处理对大鼠心脏IRI具有保护作用,但长期的臭氧预处理增加离体心脏的缺血再灌注损伤。臭氧缺血预处理和后处理均对肾及肠IRI具有保护作用。但臭氧对肝脏IRI影响的研究显示臭氧缺血预处理对肝IRI具有保护作用,对于缺血后处理的研究较少。作者对一些主要脏器IRI的研究进行综述。
Organ ischemia-reperfusion injury (IRI) can cause acute and chronic organ failure or even death. Ozone, as an unstable chemical with anti-inflammation, increased oxygen supply and microcirculation, may play an important role in the prevention and treatment of IRI. In recent years, studies have shown that preconditioning and postconditioning of ozone in the heart can protect rat heart IRI, but long-term preconditioning of ozone increases ischemia-reperfusion injury in isolated heart. Ozone ischemic preconditioning and postconditioning both have protective effects on renal and intestinal IRI. However, studies on the effect of ozone on hepatic IRI have shown that ozone-based ischemic preconditioning has a protective effect on hepatic IRI, and there are few studies on ischemic postconditioning. The author reviews the research of some major organ IRI.