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研究了成纤维细胞介导的人白细胞介素６（Ｉｎｔｅｔｒｌｅｕｋｉｎ－６，ＩＬ－６）基因疗法对预先体内注射１５０ｍｇ／ｋｇ５－氟尿嘧啶（５－ＦＵ）所造成的造血损伤小鼠模型的治疗作用。结果发现，外周血血小板数量在移殖高分泌ＩＬ－６成纤维细胞后第１０天开始持续上升，第２２天血小板数量恢复到化疗前水平，中性粒细胞数量也显著增高，但对白细胞恢复没有明显的促进作用。骨髓和脾脏ＣＦＵ－ＧＭ及ＣＦＵ－ＭＫ在体内移殖高分泌ＩＬ－６成纤维细胞后，体外动态观察发现：骨髓和脾脏ＣＦＵ－ＧＭ、ＣＦＵ－ＭＫ在第４～７天左右数量为０，在第１０天左右数量开始上升，于第１６天左右数量显著增高，对ＣＦＵ－ＧＭ、ＣＦＵ－ＭＫ具有明显的恢复作用，ＣＦＵ－Ｓ数量也显著增高。表明成纤维细胞介导的白细胞介素６基因疗法能显著治疗化疗导致的造血损伤，可望为肿瘤放、化疗导致的机体造血损伤提供新的治疗途径。
The therapeutic effect of fibroblast-mediated Intetrleukin-6 (IL-6) gene therapy on a mouse model of hematopoietic damage resulting from the in vivo injections of 150 mg / kg 5-fluorouracil (5-FU) was studied. The results showed that the number of peripheral blood platelets began to increase on the 10th day after the high secretion of IL-6 fibroblasts. The number of platelets recovered to the level before chemotherapy and the number of neutrophils increased significantly on the 22nd day. However, No significant role in promoting. CFU-GM and CFU-MK in bone marrow and spleen were highly secreted IL-6 fibroblasts in vitro, and the number of CFU-GM and CFU-MK in bone marrow and spleen was 0, The number began to rise on the 10th day and increased significantly on the 16th day, which significantly restored the CFU-GM and CFU-MK and significantly increased the number of CFU-S. It is indicated that fibroblast-mediated interleukin-6 gene therapy can significantly treat the hematopoietic damage induced by chemotherapy and is expected to provide a new therapeutic approach for the hematopoietic damage caused by chemotherapy and radiotherapy.