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据Wong JJ 2013年8月1日[Cell,2013,154(3):583-595.]报道,澳大利亚悉尼百年研究所(Sydney’s Centenary Institute)的研究人员研究发现,人类机体DNA中97%的垃圾DNA虽然并不编码产生任何蛋白质的指令,可是其在控制细胞发育过程中也扮演着重要作用。研究者揭示了一种以前未知的调节基因活性的分子机制,增加了对于细胞发育的了解,而且为开发新型靶向疗法提供了思路。研究者使用新一代的基因测序技术和复杂的计算机分析技术,揭示了特定的白细胞如何使用非编码的DNA来调节一系列控制形状和功能的基因的活性。
According to a study by Wong JJ on August 1, 2013 [Cell, 2013, 154 (3): 583-595.], A study by Sydney’s Centenary Institute in Sydney found that 97% of rubbish in human DNA Although DNA does not code for the production of any protein, it plays an important role in controlling cell development. Researchers have uncovered a previously unknown molecular mechanism that regulates gene activity, increased understanding of cell development, and provided insights for developing novel targeted therapies. Using a new generation of gene sequencing technology and sophisticated computer analysis techniques, the researchers revealed how specific white blood cells use non-coding DNA to regulate the activity of a range of genes that control shape and function.