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目的:检测孕激素受体(PR)阴性的子宫内膜样腺癌组织中CD146的表达及其临床意义。方法:用免疫组化技术检测110例子宫内膜样腺癌、48例子宫内膜不典型增生、40例子宫内膜息肉及30例子宫内膜增生期改变标本的CD146以及子宫内膜样腺癌组PR表达情况,使用SPSS 17.0对实验数据及临床资料进行统计分析。结果:子宫内膜样腺癌组中CD146表达明显高于子宫内膜增生性改变组、子宫内膜息肉组;CD146及PR表达与宫内膜样腺癌组织学分级、肿瘤浸润深度呈正相关;子宫内膜样腺癌中CD146表达与PR表达无显著相关。结论:CD146的表达与子宫内膜样腺癌浸润、转移密切相关;但CD146表达异常与PR缺失无明显关联。
Objective: To detect the expression of CD146 in endometrioid adenocarcinoma of the progesterone receptor (PR) negative and its clinical significance. Methods: Immunohistochemical technique was used to detect the expression of CD146 in endometrial adenocarcinoma of 110 cases, 48 cases of atypical hyperplasia of endometrium, 40 cases of endometrial polyps and 30 cases of endometrial hyperplasia. Cancer group PR expression, the use of SPSS 17.0 experimental data and clinical data for statistical analysis. Results: The expression of CD146 in endometrial adenocarcinoma group was significantly higher than that in endometrial hyperplasia group and endometrial polyps group. The expression of CD146 and PR was positively correlated with histological grade and depth of tumor invasion in endometrial adenocarcinoma. There was no significant correlation between CD146 expression and PR expression in endometrioid adenocarcinoma. Conclusion: The expression of CD146 is closely related to the infiltration and metastasis of endometrial adenocarcinoma. However, the abnormal expression of CD146 is not associated with PR loss.