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目的研究橡胶职业暴露、生活方式习惯、家庭环境和经济状况与肺癌之间以及因素相互之间的关系，并对本文应用的两种分析方法进行比较和评价。方法对队列在随访期间死亡的５１例病例及其对照用巢式病例－对照和病例－队列两种方法进行多因素分析。结果在控制非职业性危险因素条件下，亚硝胺暴露的危险度有显著增高（ＲＲ＝２．７１，９５％ＣＩ：１．３２～５．５７），并发现亚硝胺暴露与肺癌间有明确的剂量－反应关系存在。结论（１）本文数据提示病例－队列分析因标准误较小、抽样更简便而优于巢式病例－对照研究方法；（２）亚硝胺暴露与肺癌之间有较确定的关系，但受到吸烟和经济状况等因素作用的修饰，需进一步研究
Objective To study the relationship between rubber occupational exposure, lifestyle habits, family environment and economic status and lung cancer, as well as the relationship between the factors, and to compare and evaluate the two analysis methods used in this paper. Methods A total of 51 cases and their controls who died during the follow-up period were analyzed by nested case-control and case-cohort methods. Results Nitrosamine exposure risk was significantly increased under control of non-occupational risk factors (RR = 2.71, 95% CI: 1.32 ~ 5.57), and nitrosamine exposure and lung cancer were found There is a clear dose-response relationship. Conclusions (1) The data in this study suggest that the case-cohort analysis is superior to the nested case-control study because of smaller standard errors and easier sampling; (2) There is a definite relationship between nitrosamine exposure and lung cancer, but Modification of the effects of factors such as smoking and economic conditions requires further study