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本文报道血吸虫病肝纤维化兔与病人(晚期)的血清透明质酸(HA)和肿瘤坏死因子—α(TNF)与肝纤维化程度的关系。感染日本血吸虫新西兰兔随机分为两组,其中一组经杀虫治疗,均在感染后28周解剖,两组间肝纤维化程度有明显差异(P<0.001)。血清TNF水平与肝组织学检查肝纤维化程度、肝胶原含量及血清肝纤维化指标HA等相关。晚期病人亦获类似的结果。提示血清TNF水平可作为肝纤维化一个较好的指标。
This article reports the relationship between serum hyaluronic acid (HA) and tumor necrosis factor-α (TNF) and the degree of hepatic fibrosis in schistosomiasis rabbits and their patients (late stage). New Zealand white rabbits infected with Schistosoma japonicum were randomly divided into two groups. One group was treated by insecticide and were dissected 28 weeks after infection. The degree of hepatic fibrosis was significantly different between the two groups (P <0.001). Serum TNF levels and liver histological examination of liver fibrosis, hepatic collagen content and serum liver fibrosis indicators HA and other related. Patients with advanced disease also received similar results. Tip serum TNF levels can be used as a good indicator of liver fibrosis.