Clinical characteristics of a group of adults with nodular lymphoid hyperplasia:A single center expe

• 作 者: Alberto Rubio-Tapia Jorge Hernández-Calleros Luis Uscanga Sagrario Trinidad-Hernández
• 机 构: Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran(I
• 出 处: World Journal of Gastroenterology
• 发表日期: 2006年12期
• 关键词: nodular lymphoid diarrhea celiac histological uncommon duodenal records strict b

AIM:To describe the clinical and histological charac-teristics of a group of adults with small-bowel nodularlymphoid hyperplasia(NLH).METHODS:Patients were searched for five years inpathology records of our institution.The biopsy mate-rial was reassessed using strict histopathological criteria.Clinical data were obtained from medical records.RESULTS:Small-bowel NLH was diagnosed in 18 cases.The female:male ratio was 2:1.The most frequentsymptoms were diarrhea(72%),involuntary weight loss(72%)and abdominal pain(61%).Nine patients(50%)had immunodeficiency.Small-bowel bacterial overgrowthwas found in three(17%)cases.At small-bowel NLHdiagnosis,three(17%)had associated lymphoma:twointestinal and one extra-intestinal lymphomas.In twopatients with villous atrophy and anti-endomysial anti-bodies the diagnosis of celiac disease was established.Giardia lamblia infection was found in only one patientwith hypogammaglobulinemia(Herman’s syndrome).CONCLUSIONS:NLH is uncommon in adult patients.Associated diseases are immunodeficiency and lymphoidtissue malignancies.

AIM: To describe the clinical and histological charac- teristics of a group of adults with small-bowel nodularlymphoid hyperplasia (NLH). METHODS: Patients were searched for five years in pathology records of our institution. Biopsy mate-rial was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. RESULTS: Small-bowel NLH was diagnosed in 18 cases. Female: male ratio was 2: 1. The most frequentsymptoms were diarrhea (72%), involuntary weight loss Three patients (17%) had associated lymphoma: twointestinal and one extra-abdominal pain (61%). Nine patients (50%) had immunodeficiency. intestinal lymphomas. In twopatients with villous atrophy and anti-endomysial anti-bodies the diagnosis of celiac disease was established. Giardia lamblia infection was found in only one patient with hypogammaglobulinemia (Herman’s syndrome). CONCLUSIONS: NLH is uncommon in adult patients. Assococ iated diseases are immunodeficiency and lymphoid tissue malignancies.