论文部分内容阅读
目的观察ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学与ALT的相关性。方法选择符合诊断标准的303例慢性乙型肝炎患者,检测血清肝功能、进行肝脏活检,肝脏组织标本进行常规病理检测。结果ALT小于2×ULN慢性乙型肝炎患者肝组织64.68%有2级以上的炎症改变,56.44%有2期以上的纤维化。本组中ALT男性均值为(39.73±19.14)U/L,女性为(29.21±13.90)U/L。结论ALT与炎性分级、纤维化分期均有相关性。ALT正常与不正常的慢性乙型肝炎患者肝脏组织炎性分级、纤维化分期不同,随着ALT数值的升高肝组织炎症及纤维化改变越明显。
Objective To observe the correlation between liver histopathology and ALT in patients with ALT less than 2 × ULN chronic hepatitis B. Methods A total of 303 patients with chronic hepatitis B who meet the diagnostic criteria were selected for detection of serum liver function, liver biopsy and routine liver biopsy. Results 64.68% of liver tissues with ALT less than 2 × ULN had grade 2 or more inflammatory changes, and 56.44% had more than 2 stages of fibrosis. The ALT men in this group mean (39.73 ± 19.14) U / L and women (29.21 ± 13.90) U / L. Conclusions ALT has correlation with inflammatory grading and fibrosis stage. Normal and abnormal ALT patients with chronic hepatitis B patients with inflammatory grading, fibrosis staging, with the ALT value increased liver inflammation and fibrosis more obvious changes.